Journal of Yeungnam Medical Science

So-Young Park

8 Articles

Appreciation to peer reviewers in 2023: So-Young Park; J Yeungnam Med Sci. 2024;41(1):1-3. Published online January 4, 2024; DOI: https://doi.org/10.12701/jyms.2023.01361

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Journal of Yeungnam Medical Science is indexed in Emerging Sources Citation Index (ESCI): So-Young Park; J Yeungnam Med Sci. 2023;40(4):317-318. Published online October 12, 2023; DOI: https://doi.org/10.12701/jyms.2023.01053

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Appreciation to peer reviewers in 2023
So-Young Park
Journal of Yeungnam Medical Science.2024; 41(1): 1. CrossRef

Journal of Yeungnam Medical Science is now indexed in Scopus, a great step closer to a journal’s goal: So-Young Park; J Yeungnam Med Sci. 2023;40(2):113-114. Published online March 31, 2023; DOI: https://doi.org/10.12701/jyms.2023.00269

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Appreciation to peer reviewers in 2023
So-Young Park
Journal of Yeungnam Medical Science.2024; 41(1): 1. CrossRef
Journal of Yeungnam Medical Science is indexed in Emerging Sources Citation Index (ESCI)
So-Young Park
Journal of Yeungnam Medical Science.2023; 40(4): 317. CrossRef

Appreciation to peer reviewers in 2022: So-Young Park; J Yeungnam Med Sci. 2023;40(1):1-3. Published online January 13, 2023; DOI: https://doi.org/10.12701/jyms.2022.00920

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Journal of Yeungnam Medical Science is indexed in Emerging Sources Citation Index (ESCI)
So-Young Park
Journal of Yeungnam Medical Science.2023; 40(4): 317. CrossRef

Journal title changes from Yeungnam University Journal of Medicine to Journal of Yeungnam Medical Science: So-Young Park; J Yeungnam Med Sci. 2022;39(1):1-2. Published online December 22, 2021; DOI: https://doi.org/10.12701/yujm.2021.01655

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Journal of Yeungnam Medical Science is indexed in Emerging Sources Citation Index (ESCI)
So-Young Park
Journal of Yeungnam Medical Science.2023; 40(4): 317. CrossRef

Can antioxidants be effective therapeutics for type 2 diabetes?: Soyoung Park, So-Young Park; Yeungnam Univ J Med. 2021;38(2):83-94. Published online October 8, 2020; DOI: https://doi.org/10.12701/yujm.2020.00563

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Abstract PDF

The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity pandemic and type 2 diabetes. Naturally occurring reactive oxygen species (ROS) regulate intracellular signaling and are kept in balance by the antioxidant system. However, the imbalance between ROS production and antioxidant capacity causes ROS accumulation and induces oxidative stress. Oxidative stress interrupts insulin-mediated intracellular signaling pathways, as supported by studies involving genetic modification of antioxidant enzymes in experimental rodents. In addition, a close association between oxidative stress and insulin resistance has been reported in numerous human studies. However, the controversial results with the use of antioxidants in type 2 diabetes raise the question of whether oxidative stress plays a critical role in insulin resistance. In this review article, we discuss the relevance of oxidative stress to insulin resistance based on genetically modified animal models and human trials.

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Effect of substitution of wheat flour with chickpea flour on their physico-chemical characteristics
Jiwan S. Sidhu, Tasleem Zafar, Abdulwahab Almusallam, Muslim Ali, Amani Al-Othman
Arab Gulf Journal of Scientific Research.2023;[Epub] CrossRef
The consumption of date palm fruits as a source of bioactive compounds in patients with type 2 diabetes: a cross sectional study
M.Q. Al-Mssallem
Acta Horticulturae.2023; (1371): 381. CrossRef
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies
Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma, Thokchom Arjun Singh, Alok Kumar Mishra, Shweta Sharma, Mohammad Murtaza Mehdi
Biogerontology.2023; 24(5): 609. CrossRef
Development and Characterization of Oxidatively Responsive Thiol–Ene Networks for Bone Graft Applications
Tyler Touchet, Samuel Briggs, Lance Graul, Duncan J. Maitland
ACS Applied Bio Materials.2022; 5(6): 2633. CrossRef
Prevalence of Sarcopenia and Its Association With Diabetes: A Meta-Analysis of Community-Dwelling Asian Population
Seung Min Chung, Jun Sung Moon, Min Cheol Chang
Frontiers in Medicine.2021;[Epub] CrossRef
Association of Prx4, Total Oxidant Status, and Inflammatory Factors with Insulin Resistance in Polycystic Ovary Syndrome
Sahar Mazloomi, Nasrin Sheikh, Marzieh Sanoee Farimani, Shamim Pilehvari, Raffaele Pezzani
International Journal of Endocrinology.2021; 2021: 1. CrossRef
Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
Mayadah Bashir Shehadeh, Ghadeer A. R. Y. Suaifan, Ala’ Mustafa Abu-Odeh
Molecules.2021; 26(14): 4333. CrossRef
An Epidemiological Study Report on the Antioxidant and Phenolic Content of Selected Mediterranean Functional Foods, Their Consumption Association with the Body Mass Index, and Consumers Purchasing Behavior in a Sample of Healthy Greek Adults
Aikaterini Kandyliari, Ioannis-Nektarios Elmaliklis, Olga Kontopoulou, Marianna Tsafkopoulou, Georgios Komninos, Christina Ntzatha, Andreas Petsas, Haralabos C. Karantonis, Antonios E. Koutelidakis
Applied Sciences.2021; 11(17): 7818. CrossRef
Sterculia tragacantha Lindl Leaf Extract Ameliorates STZ-Induced Diabetes, Oxidative Stress, Inflammation and Neuronal Impairment
Amos Sunday Onikanni, Bashir Lawal, Augustine O Olusola, Janet O Olugbodi, Saidu Sani, Basiru Olaitan Ajiboye, Omotayo B Ilesanmi, Mohammed Alqarni, Gomaa Mostafa-Hedeab, Ahmad J Obaidullah, Gaber El-Saber Batiha, Alexander TH Wu
Journal of Inflammation Research.2021; Volume 14: 6749. CrossRef
Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice
Hye-Na Cha, Chang-Hoon Woo, Hwa-Young Kim, So-Young Park
Redox Biology.2020; : 101823. CrossRef

Effect of Paraxanthine on Body Fat Reduction and Insulin Sensitivity in Monosodiun Glutamate-Obese Rats: Jae-Kyung Song, So-Young Park, Jong-Yeon Kim, Hee-Sun Kim, Yong-Woon Kim; Yeungnam Univ J Med. 2007;24(2 Suppl):S481-492. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S481

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Abstract PDF

Purpose：To evaluate the effects of body fat reduction on insulin sensitivity, it was measured the glucose disappearance rate, glucose infusion rate, and hepatic glucose production rate after paraxanthine (1,7-dimethylxanthine, metabolite of caffeine) treatment in monosodium -L-glutamate (MSG)-obese rats. Materials and Methods：Obesity was induced by neonatal (2, 4, 6, 8, 10 days) injection of MSG(4 g/kg, subcutaneously) for 15 weeks. MSG-obese rats showed severe fat deposition in subcutaneous and intraabdominal cavity, shortened body length, normoglycemia, hyperinsulinemia, and high FFA level. Insulin sensitivity was assessed with hyperinsulinemic euglycemic clamp technique under anesthesia with pentothal sodium. Plasma insulin concentration was clamped at 100　μU/ml by continuous insulin infusion (1.5 mU/kg/min). At steady state, the glucose disappearance rate and glucose infusion rate were decreased and the hepatic glucose production rate was increased in the MSG-obese rats compared to the normal rats.
Results
：At 15 weeks of age, paraxanthine (15 mg/kg) was administered with ephedrine (60 mg/kg) via per oral for 15 consecutive days. Body fat mass of the paraxanthine treated rats was decreased about 29.6% in the MSG-obese and 6.3% in the normal rats compared with the control rats during 15 days. In the paraxanthine treated MSG-obese rats, the fasting insulin level was significantly (p<0.05) decreased and the glucose infusion rate was significantly (p<0.05) increased compared to that of the MSG-control rats, however the glucose disappearance rate showed increasing tendency and the hepatic glucose production rate showed decreasing tendency compared to that of the MSG-control rats.
Conclusion
：These results suggest that paraxanthine exerts an anti-obesity effect and improve insulin sensitivity in rats with MSG-induced obesity.

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Sesamolin Alleviates Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites in High-Fat and High-Fructose Diet-Fed Mice
Jing Yu, Hao Sun, Yang Yang, Yaping Yan
International Journal of Molecular Sciences.2022; 23(22): 13853. CrossRef

Effect of Saturated and Unsaturated Fatty Acid on Ob Gene and Fatty Acid Synthase Gene Expression in 3T3-L1 Adipocyte: Jeong-Kyu Chi, So-Young Park, Jong-Yeon Kim, Hee-Sun Kim, Yong-Woon Kim; Yeungnam Univ J Med. 2007;24(2 Suppl):S493-504. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S493

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Abstract PDF: Purpose：The ob gene, specifically expressed in adipocyte, encodes leptin, a hormone that induces satiety and increases energy expenditure. In this study, effects of saturated fatty acid and polyunsaturated fatty acid on ob gene expression were investigated by quantitative competitive RT-PCR in a mouse cell line (3T3-L1) which can be induced to differentiate into adipocytes. In addition to ob gene, expression of the fatty acid synthase gene as a marker of lipogenesis was measured simultaneously. Materials and Methods：The 3T3-L1 fibroblast cell were cultured in the Dulbecco’s modified Eagle medium with 10% fetal bovine serum. The differentiation of 3T3-L1 fibroblast to adipocyte was induced by the treatment of 250 nM dexamethasone and 0.5mM 1-methyl-3 -isobutylxanthine. At 10∼14 days after induction, 3T3-L1 cells were fully differentiated and had had lipid droplets in the cytoplasm. At that time, 3T3-L1 adipocytes were cultured for 12 hours in the fatty acids contained medium and were harvested for RNA extraction. Palmitate as a saturated fatty acid and docosahexaenoic acid (DHA) as a polyunsaturated fatty acid were used in this experiment and treated concentration was 600 μMol.
Results
：After conversion to adipocytes, glycerol-3 phosphate dehydrogenase activity was increased and leptin mRNA was expressed. Ob gene expressions of differentiated adipocytes were suppressed by palmitate treatment, however, there was no significant change in DHA treated adipocyte. Fatty acid synthase gene expressions, on the other hand, were suppressed by DHA treatment and not changed by palmitate treatment.
Conclusion
：These results suggested that polyunsaturated fatty acid inhibited lipogenic process and saturated fatty acid inhibited lipolytic process at cultured adipose cell level.

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